Table 4. Tumor-to-Normal Organ Ratios and Pancreas-to-Kidney Ratio for [177Lu]Lu-DOTA-Exendin-4 and [177Lu]Lu-DOTA-MI-Exendin-4a.
time p.i. | tumor-to-blood | tumor-to-pancreas | tumor-to-kidney | pancreas-to-kidney |
---|---|---|---|---|
[177Lu]Lu-DOTA-Exendin-4 | ||||
15 min | 9.70 ± 1.92 | 2.01 ± 0.25 | 0.27 ± 0.06 | 0.13 ± 0.02 |
30 min | 28 ± 6 | 1.71 ± 0.24 | 0.20 ± 0.04 | 0.12 ± 0.02 |
4 h | 163 ± 51 | 1.35 ± 0.42 | 0.15 ± 0.02 | 0.10 ± 0.01 |
24 h | 381 ± 90 | 1.38 ± 0.22 | 0.11 ± 0.03 | 0.08 ± 0.01 |
48 h | 812 ± 390 | 2.02 ± 0.85 | 0.18 ± 0.07 | 0.09 ± 0.01 |
72 h | 860 ± 326 | 1.52 ± 0.72 | 0.15 ± 0.06 | 0.10 ± 0.02 |
[177Lu]Lu-DOTA-MI-Exendin-4 | ||||
15 min | 7.98 ± 1.57 | 1.88 ± 0.40 | 0.18 ± 0.03 | 0.10 ± 0.01 |
30 min | 19 ± 6 | 2.31 ± 0.59 | 0.18 ± 0.03 | 0.08 ± 0.01 |
4 h | 79 ± 19 | 2.16 ± 0.49 | 0.13 ± 0.03 | 0.06 ± 0.01 |
24 h | 231 ± 63 | 4.41 ± 0.83 | 0.20 ± 0.04 | 0.05 ± 0.01 |
48 h | 320 ± 52 | 4.11 ± 0.44 | 0.19 ± 0.01 | 0.05 ± 0.01 |
72 h | 521 ± 174 | 6.11 ± 2.34 | 0.28 ± 0.09 | 0.05 ± 0.01 |
Mean ± SD are shown.