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. 2023 Jun 2;20(7):3519–3528. doi: 10.1021/acs.molpharmaceut.3c00117

Table 4. Tumor-to-Normal Organ Ratios and Pancreas-to-Kidney Ratio for [177Lu]Lu-DOTA-Exendin-4 and [177Lu]Lu-DOTA-MI-Exendin-4a.

time p.i. tumor-to-blood tumor-to-pancreas tumor-to-kidney pancreas-to-kidney
[177Lu]Lu-DOTA-Exendin-4
15 min 9.70 ± 1.92 2.01 ± 0.25 0.27 ± 0.06 0.13 ± 0.02
30 min 28 ± 6 1.71 ± 0.24 0.20 ± 0.04 0.12 ± 0.02
4 h 163 ± 51 1.35 ± 0.42 0.15 ± 0.02 0.10 ± 0.01
24 h 381 ± 90 1.38 ± 0.22 0.11 ± 0.03 0.08 ± 0.01
48 h 812 ± 390 2.02 ± 0.85 0.18 ± 0.07 0.09 ± 0.01
72 h 860 ± 326 1.52 ± 0.72 0.15 ± 0.06 0.10 ± 0.02
[177Lu]Lu-DOTA-MI-Exendin-4
15 min 7.98 ± 1.57 1.88 ± 0.40 0.18 ± 0.03 0.10 ± 0.01
30 min 19 ± 6 2.31 ± 0.59 0.18 ± 0.03 0.08 ± 0.01
4 h 79 ± 19 2.16 ± 0.49 0.13 ± 0.03 0.06 ± 0.01
24 h 231 ± 63 4.41 ± 0.83 0.20 ± 0.04 0.05 ± 0.01
48 h 320 ± 52 4.11 ± 0.44 0.19 ± 0.01 0.05 ± 0.01
72 h 521 ± 174 6.11 ± 2.34 0.28 ± 0.09 0.05 ± 0.01
a

Mean ± SD are shown.