Table 1.
Microfluidic device design and fabrication
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Ref.
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Manufacturing
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Characteristics of microdevices
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Fabrication
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Main material of device
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Technology used
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Mold details
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Membranes
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Dimensions as width × height
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| Kurosawa et al[18], 2022 | MIMETAS® (OrganoPlate® 3-lane plate) | Unspecified polymer | NR | NR | Membrane-free | Top and bottom channels: 320 μm × 220 μm. Gel channels: 360 μm × 220 μm. PhaseGuides®: 100 μm × 55 μm |
| Fengler et al[19], 2022 | MIMETAS® (OrganoPlate® 3-lane plate) | Unspecified polymer | NR | NR | Membrane-free | Top and bottom channels: 320 μm × 220 μm. Gel channels: 360 μm × 220 μm. PhaseGuides®: 100 μm × 55 μm (width × height) |
| Wevers et al[20], 2021 | MIMETAS® (OrganoPlate® 3-lane plate) | Unspecified polymer | NR | NR | Membrane-free | Top and bottom channels: 320 μm × 220 μm. Gel channels: 360 μm × 220 μm. PhaseGuides®: 100 μm × 55 μm |
| Noorani et al[21], 2021 | Emulate® (brain on-a-chip) | PDMS | NR | NR | PDMS membrane | Brain channel: 1 mm × 1 mm. Blood channel: 1 mm × 0.2 mm |
| Middelkamp et al[22], 2021 | In house | PDMS | Soft lithography | Material: PMMA. Fabrication: Micrommilling | PETE membrane (5 μm thick) | Straight bottom channel: 500 μm × 500 μm. Open-top compartment: 500 μm × 1500 μm |
| Choi et al[23], 2021 | In house | PMMA | CNC | NA | PETE membrane | HUVEC microchannels: 800 μm × 200 μm. iBMECs microchannels: 800 μm × 500 μm |
| Motallebnejad et al[24], 2020 | In house | NR | Soft lithography | NR | Membrane-free | 800 μm × 100 μm |
| Lee et al[25], 2020 | In house | PDMS | Soft lithography | Material: SU-8. Fabrication: Photolithography | Membrane-free | Fluidic channel: 1340 μm × 150 μm. Main channel: 2200 μm × 150 μm |
| Jagadeesan et al[26], 2020 | In house | PDMS | Soft lithography | Material: SU-8. Fabrication: Photolithography | PDMS membrane (50 μm thick) | Top microchannel: 1 mm × 1 mm. Bottom microchannel: 1 mm × 0.2 mm |
| Vatine et al[27], 2019 | In house | PDMS | Soft lithography | Material: SU-8. Fabrication: Photolithography | PDMS membrane (50 μm thick) | Top microchannel: 1 mm × 1 mm. Bottom microchannel: 1 mm × 0.2 mm |
| Park et al[28], 2019 | In house | PDMS | Soft lithography | Material: Prototherm. Fabrication: 3D printed (Proto labs) | PE membrane (20 μm thick) | Hollow microchannels: 1 mm × 1 mm. Top channel: 1 mm × 1 mm. Bottom channel: 1 mm × 0.2 mm |
| Campisi et al[29], 2018 | In house | PDMS | Soft lithography | Material: Silicon Wafer. Fabrication: NR | Membrane-free | Fluidic channel: 1000 μm × 150 μm. Main channel: 1300 μm × 150 μm. Distance between posts: 200 μm |
| Wang et al[30], 2017 | In house | Objet VeroClear photopolymer | 3D object printer (Objet 30Pro, Stratasys Ltd., Rehovot, Israel) | NA | PC membrane (0.4 μm pore size) | Main channel: 300 μm × 160 μm |
| DeStefano et al[31], 2017 | In house | PDMS | Soft lithography | Material: Aluminum mold. Fabrication: NR | Membrane-free | 390 μm, 450 μm, 550 μm, and 770 μm (different width) |
3D: Three-dimensional; CNC: Computer numerical control; hBMECs: Human brain microvascular endothelial cells; HUVEC: Human umbilical vein endothelial cells; NA: Not applied; NR: Not reported; PDMS: Polydimethylsiloxane; PC: Porous polycarbonate; PE: Polyethylene terephthalate; PETE: Polyester track-etched; PMMA: Poly(methyl methacrylate); SU-8: Negative photoresist.