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. 2023 Jul 6;155(8):e202313380. doi: 10.1085/jgp.202313380

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© 2023 Catacuzzeno et al.

This article is available under a Creative Commons License (Attribution 4.0 International, as described at https://creativecommons.org/licenses/by/4.0/).

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Figure 1. — Hodgkin and Huxley’s charged gating particles. (A–C) Sketch illustrating the membrane relocation of the three-activating charged gating particles of Na channel upon membrane depolarization and repolarization. (D) Time courses of gating particles’ translocation (red trace) and Na currents (green trace) obtained using Eqs. 5 and 6 of Box 1 for the activation phase, and Eqs. 7 and 8 for the deactivation phase, respectively, considering three activation particles and one inactivation particle. (E) Theoretical voltage dependence of charged gating particles translocation, Q(V), and channel conductance, G(V), for a voltage-gated ion channel, obtained using Eqs. 9 and 10 of Box 1, respectively.