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Kinetic models of gating. Left: Hodgkin and Huxley’s model of the two-step charged gating particles translocation to open the K channel. GP, gating particles; R, resting; A, activated. Center and right: Gating models of Shaker consistent with a full set of experimental data showing conformational states of each of the four voltage sensors (S4) and the conformational states of the channel, respectively (from Zagotta et al., 1994a).
