Table 1.

Product design parameters for manufacturing LNG-IUSs^*.

No.	LNG-IUSs with different drug loading	Comments
1	0.5% w/w DL	Drug loading ranging from 0.5% w/w to 50% w/w was used to investigate the impact on drug release characteristics. 50% w/w drug loading was used as a reference.
2	1% w/w DL
3	2.5% w/w DL-T*
4	2.5% w/w DL-C*
5	5% w/w DL
6	10% w/w DL
7	25% w/w DL
8	50% w/w DL
9	48.8% w/w DL	5% more in excipient amount
10	51.1% w/w DL	5% less in excipient amount
11	47.6% w/w DL	10% more in excipient amount
12	52.6% w/w DL	10% less in excipient amount

^*T and C represent the API obtained from Tecoland and Cayman, respectively. API from Tecoland was used in the formulations without T or C.