Table 1.
Mendelian randomization estimates from three methods analyzing the causal effect of RA and SLE on the risk of ASD
| Method | Number of SNPs | Beta coefficient | Standard error | Association p-value | Cochran Q statistic | Heterogeneity p-value |
|---|---|---|---|---|---|---|
| RA | ||||||
| Inverse variance weighted | 33 | −0.077 | 0.041 | 0.062 | 37.25 | 0.240 |
| MR-Egger | 33 | −0.062 | 0.079 | 0.434 | 37.19 | 0.205 |
| Weighted median | 33 | −0.071 | 0.058 | 0.223 | NA | NA |
| SLE | ||||||
| Inverse variance weighted | 28 | 0.014 | 0.021 | 0.493 | 19.34 | 0.857 |
| MR-Egger | 28 | 0.048 | 0.043 | 0.273 | 18.53 | 0.856 |
| Weighted median | 28 | 0.045 | 0.030 | 0.130 | NA | NA |
RA: rheumatoid arthritis, SLE: systemic lupus erythematosus, ASD: autism spectrum disorder, MR: Mendelian randomization, SNP: single nucleotide polymorphism, NA: not available.