Table 2.
Activators based on signaling mechanisms for NLRP3 inflammasome activation
| Proposed signaling mechanisms | NLRP3 inflammasome activators |
|---|---|
| Reactive oxygen species | Extracellular ATP |
| Glucose | |
| MSU | |
| Silica | |
| Asbestos | |
| Hyaluronan | |
| Nigericin | |
| Aspergillus fumigatus | |
| Candida albicans | |
| Staphylococcus aureus | |
| Alum | |
| Imidazoquinoline compounds | |
| Ion channel formation | Extracellular ATP |
| Nigericin | |
| Escherichia coli | |
| Bacterial endotoxins | |
| Silica | |
| CPPD | |
| Lysosomal destabilization | Silica |
| Alum | |
| Bacterial endotoxins | |
| Adenovirus | |
| Amyloid-β |
ATP: adenosine triphosphate, MSU: monosodium urate, CPPD: calcium pyrophosphate dihydrate, NLRP3: NACHT, LRR, and PYD domains-containing protein 3.