Figure 7.

Differences in strial microvascular between whole-mount preparations from younger and older adult donors. Persistent homology was performed using representations of the UEA I⁺-stained images of whole-mount preparations (Figs. 5A, 6E). A, B, Results from the temporal bone from a younger adult donor (A) demonstrated one-cycle loop structures representing connected vessels, as in the young adult CBA/CaJ mouse (Fig. 2G, left panel). In contrast, results from the temporal bone from the older adult donor (B) did not show one-cycle looping structures, as in the aged mouse (Fig. 2G, right panel). Values along the x- and y-axes are relative units after scaling by maximal death value from each analysis.