Table 4. Histological outcomes and number of colposcopies performed per CIN2+/CIN3+ case detected in the intervention and reference groups.
| Intervention group | Reference group | |||
|---|---|---|---|---|
| Eligible women | 11,192 | 33,387 | ||
| Tested women | 6,965 | 743 | ||
| Women with adequate histology* | 357 | 75 | ||
| Worst histology result | ||||
| <CIN2 | 313 | 64 | ||
| CIN2+** | 44 | 11 | ||
| CIN3+*** | 26 | 7 | ||
| Cervical cancer | 4 | 4 | ||
| CIN2+ cases according to age | p-value¤ | p-value¤ | ||
| 65–67 (%, [95% CI]) | 12 (0.5, [0.2, 0.8]) | 0.30 | 5 (1.6, [0.5, 3.7]) | 0.82 |
| 68–69 (%, [95% CI]) | 32 (0.7, [0.5, 1.0]) | 6 (1.4, [0.5, 3.0]) | ||
| CIN2+ cases according to screening history at age 50–64 | ||||
| Insufficiently screened n (%, [95% CI]) | 6 (1.4, [0.5, 2.9]) | p = 0.05 | 3 (4.6, [0.9, 12.9]) | p = 0.03 |
| Sufficiently screened n (%, [95% CI]) | 38 (0.6,[0.4, 0.8]) | 8 (1.2, [0.5, 2.3]) | ||
| Histology results per 1,000 eligible womena [95% CI] | p-value¤¤ | |||
| <CIN2 | 28.0 [25.0, 31.1] | 1.9 [1.5, 2.5] | p < 0.001 | |
| CIN2+ | 3.9 [2.9, 5.3] | 0.3 [0.2, 0.6] | p < 0.001 | |
| CIN3+ | 2.3 [1.5, 3.4] | 0.2 [0.1, 0.4] | p < 0.001 | |
| Cervical cancer | 0.4 [0.09, 0.9] | 0.1 [0.03, 0.3] | p = 0.10 | |
| Colposcopies | ||||
| Number of colposcopies performed | 511## | 111## | ||
| Number of colposcopies performed per CIN2+ case [95% CI] | 11.6 [8.5, 15.8] | 10.1 [5.4, 18.8] | 0.69 | |
| Number of colposcopies performed per CIN3+ case [95% CI] | 19.6 [13.2,29.2] | 15.8 [7.4, 34.0] | 0.62 |
CI, confidence interval. Adequate: women with inadequate or missing histology results were excluded.
* From biopsy, ECC or LEETZ from the worst diagnosis identified during follow-up.
** CIN2+ includes: CIN2, CIN3/AIS, CIN and cancer.
*** CIN3+ includes: CIN3/AIS and cancer.
aUnadjusted for age and screening history at age 50–64.
¤p-Value: comparison within group.
¤¤p-Value: comparison between intervention and reference group.
##Some women had >1 biopsy during follow-up and thus the number of colposcopies performed were higher than the number of women with adequate histology.