Fig 4. Blood CpGs associated with prevalent or incident disease states showing effect sizes on interpretable scale.

Effect sizes were reestimated using logistic regression (prevalent disease, blue points) or Cox proportional hazards models (incident disease, violet points) to return more interpretable effect sizes. Effect sizes represent a per-1 SD increase in age-, sex-, and experimental batch-adjusted CpG methylation M-values (or age- and batch-adjusted for breast cancer). CpGs shown were significant in both basic and fully adjusted models. Odds ratios and hazard ratios are detailed in S22 Table. CI, confidence interval; CpG, cytosine-phosphate-guanine dinucleotide; SD, standard deviation.