Table 1. Calcineurin functions in fungal pathogens.

Fungal pathogen	Calcineurin functions	References
Human pathogens
Aspergillus fumigatus	Hyphal growth, cell wall integrity, septation, cation homeostasis, antifungal drug resistance, and virulence	[7–9,22]
Candida albicans	Hyphal growth, ER stress response, cell wall integrity, azole tolerance, growth in serum, and virulence	[4–6,20,34,37]
Candida glabrata	Thermotolerance, ER stress response, cell wall integrity, azole tolerance, growth in serum, and virulence	[38,39]
Cryptococcus neoformans	Thermotolerance, cell wall integrity, antifungal drug tolerance, postmating dimorphic transition from yeast to hyphae, and virulence	[10,11,21,24]
Mucor circinelloides	Vegetative dimorphic transition from yeast to hyphae, hyphal growth, antifungal drug resistance, and virulence	[14,40]
Paracoccidioides brasiliensis	Vegetative dimorphic transition from hyphae to yeast, yeast and hyphal growth, and calcium homeostasis	[13]
Talaromyces marneffei	Hyphal growth, conidiation and conidia germination, cell wall integrity, osmotic stress response, survival in macrophages, and virulence	[16]
Trichosporon asahii	Thermotolerance, cell wall integrity, ER stress response, hyphal formation, and virulence	[15]
Plant pathogens
Botrytis cinerea	Conidiation, cation homeostasis, cell wall integrity, and virulence	[41]
Magnaporthe oryzae	Mycelial growth, conidiation, appressorium formation, and virulence	[17,23,42]
Ustilago maydis	Postmating dimorphic transition from yeast to hyphae, and virulence	[18]
Ustilago hordei	Thermotolerance, cell wall integrity, cation homeostasis, pH stress, and virulence	[43]

Functions listed in bold indicate roles that are known to be either completely or partially independent of Crz1.