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. 2023 Jun 22;11:1164166. doi: 10.3389/fcell.2023.1164166

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Copyright © 2023 Song, Liang, Liu, Lin, Zhang and Yang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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ERK signaling pathway promotes angiogenesis to improve myocardial ischemia. HIF-1 can promote VEGF expression, and VEGF binds to its receptor VEGFR and activates the Ras/Raf/ERK signaling pathway. MiRNA-126 promotes MEK phosphorylation by inhibiting Spred-1 and activates the ERK signal pathway. CD151 can directly activate the ERK1/2 signaling pathway and regulate angiogenesis. In addition, XMD8-92 can inhibit the ERK5 signaling pathway and affect the secretion of VEGF, thus regulating angiogenesis.