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. 2023 Jun 22;11:1164166. doi: 10.3389/fcell.2023.1164166

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Copyright © 2023 Song, Liang, Liu, Lin, Zhang and Yang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Role of the ERK signaling pathway to promote angiogenesis in myocardial infarction. HSPA12A promotes VEGF expression and activates the ERK signaling pathway. In contrast, its inhibitor PD98059 attenuates ERK phosphorylation and hinders angiogenesis. HIF-1α can improve myocardial ischemia by promoting the expression of phosphorylated MEK in TRPC1, activating the ERK signaling pathway, promoting cell proliferation and migration, regulating angiogenesis, and improving myocardial ischemia status.