TABLE 1.
Summary of drug intervention angiogenesis in the treatment of ischemic diseases.
| Drugs | Composition/structure | Diseases | Signal pathway | References |
|---|---|---|---|---|
| Tongnao Decoction | Gastrodiae Rhizoma, Uncariae Ramulus Cum Uncis, Chuanxiong Rhizoma, Arisaematis Rhizoma Preparatum, Rhodiolae Crenulatae Radix et Rhizoma, Rhizoma Anemone Altaicae, Hirudo, and Bombyx batryticatus | Ischemic stroke | VEGF/ERK signal pathway | Wang et al. (2020); Wang (2021) |
| Buyang Huanwu Decoction | Astragali Radix, Angelica Sinensis Radix, Paeoniae Radix Rubra, Pheretima, Chuanxiong Rhizoma, Persicae Semen, and Carthami flos | Myocardial infarction | Cav-1/VEGF/ERK signal pathway | Zhu et al. (2019); Peng et al. (2020) |
| Tongxinluo | Ginseng Radix et Rhizoma, Paeoniae Radix Rubra, Santali album Lignum, Dalbergiae Odoriferae Lignum, Olibanum, Ziziphi Spinosae Semen, Borneolum Syntheticum, Hirudo, Scorpio, Cicadae Periostracum, Eupolyphaga steleophaga, and Scolopendra | Myocardial infarction | MAPK/ERK signal pathway | Bai (2014); Bai et al. (2017) |
| Danhong injection | Salviae Miltiorrhizae Radix et Rhizoma and Carthami flos | Myocardial infarction | ERK signal pathway | Li et al. (2019b); He et al. (2019) |
| PFE | ,
|
Ischemic cardiovascular disease | MEK/ERK, PI3K/AKT/eNOS, SRC/FAK, and VEGF/VEGFR2 signal pathways | Chung et al. (2010a); Zhai et al. (2021) |
| AS-IV | ,
|
Myocardial infarction | ERK1/2 signal pathway | Wang et al. (2015) |
| TALH | ,
|
Wound ischemia | SRC/MEK/ER signal pathway | Shi et al. (2022) |
| Salvianolic acid B | ,
|
Ischemic stroke | AKT/ERK signal pathway | Li (2020) |
| MDG-1 | ,
|
Myocardial ischemia | S1P/bFGF/Akt/ERK/eNOS signal pathway | Wang et al. (2010) |
| Sesamin | ,
|
Ischemic cardio-cerebrovascular disease | MEK/ERK and P38 MAPK signal pathways | Fukuda et al. (1986); Lee et al. (2004); Nakano et al. (2006); Chung et al. (2010b) |
| KYZ | ,
|
Ischemic cardio-cerebrovascular disease | PI3K/AKT and MEK/ERK signal pathways | Kong et al. (2022) |
| Irisin | ,
|
Myocardial ischemia | ERK–MAPK signal pathway | Mavria et al. (2006); Zhang et al. (2014b); Liao et al. (2019) |
| H2S | ,
|
Ischemic cardio-cerebrovascular disease | AKT and ERK signal pathways | Zicola et al. (2021) |
| 2HP-β-CD | ,
|
Limb ischemia | VEGF-A, PDGF-BB, TGF-β1, and ERK signal pathway | Qi et al. (2015) |
| PD98059 | ,
|
Colorectal cancer | ERK signal pathway | Hao et al. (2014) |
| Sorafenib | ,
|
Cancer of the liver | ERK signal pathway | Wang (2017) |