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. 2023 Apr 10;119(8):1728–1739. doi: 10.1093/cvr/cvad054

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© The Author(s) 2023. Published by Oxford University Press on behalf of the European Society of Cardiology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com

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FOXK1 regulates cardiac developmental transcriptional networks. (A, C) Gene ontology (GO) pathway analysis highlights pathways and development related terms in D3 and D5 control EBs, the x-axis represents the counts of genes in each GO term. The colour scale shows the increased significance of biological processes using the over-representation test with an adjusted P < 0.05. (B, D) The heatmap represents up-regulated and down-regulated in the control EBs vs. the Foxk1 KO EBs at D3 and D5, respectively. The heatmap colour scheme key is provided, with red representing up-regulated and blue representing down-regulated genes.