Figure 2. Thermal and colloidal stability of formulated MS-Hu6 is maintained in the presence of L-methionine and EDTA.

To improve long-term storage stability, an antioxidant L-methionine and a chelating agent EDTA were added to formulated MS-Hu6. Addition of L-methionine and EDTA to formulated MS-Hu6 did not alter its melting temperatures (T_m) in the protein thermal shift assay (A) or the hydrodynamic radius (rh or Z–average rh) or polydispersity index (PDI) in dynamic light scattering (B).