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. 2023 Jun 22;3:1197310. doi: 10.3389/fbinf.2023.1197310

FIGURE 3.

FIGURE 3

A recommended way to gradually build a hierarchical structure starting from a single PD diagram and step by step making the map architecture more complex. Each map version works as a fully functional complete resource. (A). Starting with a priority sub-pathway in PD. (B). Building a top-level view with key mechanisms partly or entirely represented in the PD diagram. (C). Automatically or manually creating an AF diagram that matches the content of the PD diagram. (D). Extending the content to multiple diagrams with one integrating top-level view diagram that represents more detailed AF and PD layers.