Fig. 2.

(a) Spatial representation of the voxel-wise normative model for all modalities in males. The panels show the beta values depicting the change across 8 to 18 years of age for negative face processing, positive/neutral face processing, shape processing and anatomical images. Red and blue indicate an increase or decline, respectively, in activity or relative expansion or contraction to match the template for the Jacobian determinants. (b) Mean positive deviations from the model for controls and cases. Cases showed significantly more positive deviations, i.e. a higher age-related increase in prefrontal and limbic (i.e. cluster comprising the amygdala) activity presumably during negative and positive/neutral face matching. For visualization purposes only the left side is shown.