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. 2023 Jul 6;14:3995. doi: 10.1038/s41467-023-39608-w

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Heatmap coloured by global z-score p-values of adult-foetus differential pairs (likelihood ratio test FDR < 0.1, two-sided), including 135 adult-specific (low p-values in A1 and A2), and 98 foetus-specific. b Volcano plot highlighting adult-specific and foetus-specific pairs, in orange and green, respectively (FDR < 0.1). z difference (x-axis) cutoffs were taken at 30% and 70% quantiles, respectively. Source data are provided as a Source Data file. c, d Pathway enrichment results for adult-specific and foetus-specific pairs. Dot sizes indicate enrichment significance from one-sided Fisher’s Exact Test results. Only pathways with 2 or more selected pairs were visualised.