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. 2023 Jul 6;14:3991. doi: 10.1038/s41467-023-39729-2

Fig. 3. The leave-one-group-out (LOGO) module generates ligand-specific association networks.

Fig. 3

We employed a leave-one-group-out (LOGO) analysis to find associations associated with exclusion/inclusion of that specific condition. We excluded one set of ligand conditions (24 and 48 h) from the input matrices, ran the Lasso module (Fig. 2b) with a smaller number of columns, and obtained a new Robust Lasso Coefficient Matrix, named ligand-specific coefficient matrices. Comparing the resulting matrix from the LOGO module to the FULL-data Lasso coefficient matrix, we determined the “ligand-dependent” coefficients (ones that appear only in LOGO IAN and coefficients that are present only in FULL-data IAN) to create the final ligand-specific associations list. Repeating the process for each ligand treatment condition, we obtained six ligand-LOGO IANs.