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. 2023 Jul 6;14:3991. doi: 10.1038/s41467-023-39729-2

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — a The LOGO-IANs are pair-wise compared and subtype-specific pathway enrichments are determined. The colors represent subtypes (purple: HER2-amplified, gold: TNBC, red: ER/PR-positive, gray: subtype shared), node size depends on pathway gene-set size, and edge width correlates with shared gene-set similarity of the connected nodes. Examples of pathways are labeled individually or as groups. b The pathways enriched in all LOGO-IAN conditions constitute the breast cancer (BRCA) core network. The list includes cell cycle, estrogen, MAPK, and PI3K signaling as well as transcriptional regulation and programmed cell death. Node size and edge width represent the gene-set size and gene-set similarity of the connected nodes, respectively.