Table 3.

PAD4-citrullinated positions in C1-INH.

Peptide identified	Mascot score*	Start position	End position	Modified position	Protease
K.ISRLLDSLPSDTR.L	69	274	286	276	Trypsin
K.TRMEPFHFK.N	43	308	316	309	Trypsin
K.HRLEDMEQALSPSVFK.A	106	365	380	366	Trypsin
K.FQPTLLTLPRIK.V	32	391	402	400	Trypsin
K.FPVFMGRVYDPR.A	68	488	499	494	Trypsin
K.FPVFMGRVYDPR.A	50	488	500	494, 499	Trypsin
E.AAAASAISVARTLLVFE.V	118	456	472	466	Glu-C

The modified Arg residues and the position of the reactive site are highlighted in bold.

*Individual ions score above 32 indicate identity or extensive similarity (p < 0.01).