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. 2023 Jun 22;14:1194881. doi: 10.3389/fimmu.2023.1194881

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Copyright © 2023 Liang, Aditi, Onyoni, Wang, Gonzales, Sunyakumthorn, Wu, Samir and Soong

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Alteration of blood brain barrier in Ot-infected mice. Brain RNA-seq experiment was performed, as in Figure 1 . (A) Venn diagram shows the numbers of unique and shared differentially expressed genes for each comparison. (B) GSEA analysis identifies significant enrichment of blood brain barrier dysfunction module at days 6 and10. (C) qRT-PCR assay confirms the upregulation of blood brain barrier related genes at day 10 as compared to mocks. A two-tailed student t test was used for comparison between two groups. *, p < 0.05; **, p < 0.01; ***, p < 0.001. The qRT-PCR data (4-5 samples/group) were from one experiment representative of three performed independently.