Table 4.

Various Dermatological Lesions Associated with TKIs

Tyrosine Kinase Inhibitors	Associated dermatological lesions
Imatinib	Maculopapular eruptions along with pigmentary changes, Photosensitization, Superficial edema affecting the periorbital area (epiphora, chemosis, and conjunctivochalasis), Urticarial, Lichenoid, and Psoriasiform eruptions, Exacerbations of the existing Psoriasis, Hypo-/Hyperpigmentation, Neutrophilic eccrine hidradenitis, and neutrophilic panniculitis, Mycosis fungoides like reaction, Follicular mucinosis, Malpighian epithelium, Porphyria Cutanea trade, and Pseudoporphyria, Exanthematous pustulosis, Sweet Syndrome, Panniculitis, SJS Rare cases - Small vessel vasculitis, Erythema nodosum, and GVHD of skin
Nilotinib	Perifollicular, Hyperkeratotic, and Erythematous Maculopapular Eruptions, Mild to moderate pruritus, Skin xerosis, Alopecia, Body hair loss, and Bullous Sweet syndrome
Bosutinib	Erythema, Maculopapular Eruption, Pruritic Rash, Allergic Dermatitis, Acne, Folliculitis, and Skin Exfoliation
Ponatinib	Erythematous and papular rashes Skin xerosis
Dasatinib	Macular, Papular or Exfoliative rash, Pruritus, Localized and generalized erythema, Papular Eruptions, Exfoliative rash, Pruritus, Hyperhidrosis, Alopecia, Xerosis, Acne, Urticaria, Dermatitis, Photosensitivity, Nail Disorders, and Pigmentary Changes, Skin Ulcers, Palmoplantar Erythrodysesthesia Syndrome. Rare Cases - Panniculitis, Acute Febrile Neutrophilic Dermatosis, And Bullous Disorders
Sorafenib	Stomatitis, Seborrheic dermatitis-like facial and scalp erythema, Subungual splinter hemorrhages, Periungual erythema, EM and EM-like eruptions, SJS, Eruptive melanocytic nevi and Drug-induced lentigines, Pyoderma gangrenosum, Generalized keratosis pilaris like eruption, Epidermal cysts, Nipple hyperkeratosis and/ or dysesthesia or dyskeratotic plaque with milia, New squamous cell carcinomas, Keratoacanthomas, and Inflammation of Preexisting Actinic Keratosis
Sunitinib	All grade hand-foot skin reactions, Seborrheic dermatitis-like facial and scalp erythema, Skin discoloration, Hair depigmentation, Facial edema, Transient scalp dysesthesia, Yellow skin pigmentation of the face Dry skin, Dermatitis, Stomatitis, Alopecia, Subungual splinter hemorrhages Phototoxicity, Pyoderma gangrenosum, Generalized keratosis pilaris-like eruption, Epidermal cysts, Nipple hyperkeratosis and/ or dysesthesia or Dyskeratotic plaque with milia
Erlotinib	Acneiform rash, Xeroderma, Pruritus, Paronychia
Cabozantinib	Hand-foot skin reaction, Generalized pigment dilution and/or Hair depigmentation, Xerosis, Scrotal erythema/ulceration, Subungual splinter hemorrhages
Vemurafenib	Dose-dependent papulopustular rash, Photosensitivity, Xerosis, Pruritus, Paronychia, Alopecia and hair follicle alterations, Hyperkeratosis, Pyogenic granulomas, Verrucous keratosis, Acantholytic dermatosis, Seborrheic keratosis, Verruca vulgaris, Hypertrophic actinic keratosis, Cutaneous squamous cell carcinoma and/ or Keratoacanthoma
Dabrafenib	Dose-dependent papulopustular rash, Xerosis, Pruritus, Paronychia, Alopecia and Hair follicle alterations, Hyperkeratosis, Pyogenic granulomas Verruca vulgaris, Hypertrophic actinic keratosis, Cutaneous squamous cell carcinoma and/ or Keratoacanthoma
Trametinib	Acneiform rash, Pruritus, Xerosis. Squamous cell carcinoma