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. 2023 Apr 1;51(8):1769–1780. doi: 10.1007/s10439-023-03183-4

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Visualization of the three volumes of interest used to the orientation analyses (integration window radius 12) of the healthy medial femoral cartilage. From left to right VOI: 500 µm × 500 µm × cartilage thickness, 150 µm × 150 µm × cartilage thickness, and 150 µm × 5 µm × cartilage thickness. The identical VOIs were used for the anisotropy analyses.