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. 2022 Dec 8;13(6):2369–2382. doi: 10.1016/j.apsb.2022.12.002

Figure 5.

Figure 5

Efficacy of different formulations on the PA-remodeling regression and PASMC-hyperproliferation inhibition in MCT-PH rats. (A) H&E staining of the lung sections and (B) immunohistochemical detection of α-SMA expression. (C) Ki67 expression determined by immunohistochemistry. Semi-quantitative analysis of (D) PA medial thickness, (E) muscularization of pre-acinar arterioles, and (F) α-SMA expression relative to per artery in PAs. Semi-quantitative analysis of (G) Ki67 positive cells relative to PASMCs. Data are represented as mean ± SD. n = 4–6, ∗∗P < 0.01, ∗∗∗P < 0.001 compared to MCT group; #P < 0.05, ##P < 0.01 compared to GlcA-NPplex group; ns, no significance. Scale bar, 50 μm. CON: controlled rats (normal rats) received intravenous injections of 0.9% saline; MCT: rats received MCT treatment. The MCT-induced rats were dosed with preparations at 0.4 mg/kg PTX and 0.04 mg/kg Cas-3 via the tail vein.