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. 2022 Dec 28;13(6):2736–2746. doi: 10.1016/j.apsb.2022.12.018

Table 1.

Calculated IC50 values for Dox, TCO-Dox and TCO-Dox activated with non-activated against each cell line.

Drug Doxa TCO-Dox TCO-Doxb
Activated		 TCO-Doxc
Non-activated
A549 0.278 4.76 0.548 5.04
HeLa 0.229 2.93 0.439 4.28
a

IC50 values are determined the 48 h cytotoxicity of each drug. The units of IC50 are in μmol/L.

b

Activated TCO-Dox indicates that each cell line was pre-incubated with 50 μmol/L Ac4ManNTz for 3 days, washing and incubated with TCO-Dox at different concentration for 48 h.

c

Nonactivated TCO-Dox indicates the pre-incubation with 50 μmol/L Ac4ManNPh.