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PK properties of D10 and D15in vivo. (A) The mean plasma concentrations vs time in rats after administrated with D10, D15 and tepotinib via different routes (mean ± SD, n = 4). (B) The mean pharmacokinetic parameters in rats after administrated with D10, D15 and tepotinib via different routes (mean ± SD, n = 4). ∗P < 0.05, ∗∗P < 0.01 compared with tepotinib group via corresponding routes. ##P < 0.01 compared with D10 group via corresponding routes.
