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. 2023 Jan 19;13(6):2715–2735. doi: 10.1016/j.apsb.2023.01.014

Figure 12.

Figure 12

Synergy of tepotinib with D10/D15 significantly inhibited cells growth. (A–C) Effects of tepotinib with D10/D15 as single agents or drug combinations in EBC-1 (A) and Hs746T (B) cells. Data are mean ± SD, n = 3. CI was calculated by the Chou–Talalay equation using multiple doses and response points, and the data are averages of three independent determinations. CI values of three different indicated fraction affect (Fa) are shown (C). (D–E) The antiproliferative effects of tepotinib, D10 and D15 as single agents or drug combinations in EBC-1 cells at the indicated concentration. Data are mean ± SD, n = 3. ∗∗P < 0.01 (one-way ANOVA). (F) The effects of c-MET and p-c-MET by tepotinib with D10 and D15 as single agents or drug combinations in EBC-1 and Hs746T cells at the indicated concentration.