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D10 and D15 significantly inhibited cell migration and invasion. Wound healing assay (A–C) and Transwell assay (D–E) of EBC-1 and Hs746T cells treated with tepotinib, D10, D15 and vehicle control (DMSO) treatment at the indicated concentration for 12h. Histograms show the relative cell migration and cell invasion (bottom). Data are mean ± SD, n = 3, ∗∗P < 0.01 (t test). Scale bars: 100 mm.
