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. 2023 Jan 19;13(6):2715–2735. doi: 10.1016/j.apsb.2023.01.014

Figure 9.

Figure 9

D10 and D15 significantly repressed Hs746T tumor growth in vivo by p.o. administration. (A) Treatment schedule for the Hs746T cells xenograft tumors model treated with vehicle, tepotinib, D10 and D15. (B–D) BALB/c mice transplanted with Hs746T cells were orally administrated with vehicle control, tepotinib, D10, or D15 with single doses of 20, 40 mg/kg. The change of Hs746T tumor volume (B), tumor weight (C) and change of body weight (D) of all mice in each group were shown (n = 7). Data are mean ± SD, ∗∗P < 0.01 (one-way ANOVA). (E) Representative images of H&E, c-MET, p-c-MET, and cleaved-PARP immunohistochemical (IHC) staining in harvested tumors from each group in (B) are shown. Scale bars represent 50 mm.