Figure 5.

Lung-, intestine-, skin- and blood-vessel-on-a-chip for drug screening. (A) A human alveolus chip reproducing the lung injury caused by SARS-CoV-2 infection to explore the treatment efficacy of remdesivir. Reprinted with the permission from Ref. 156. Copyright © 2021 The Authors. Advanced Science published by Wiley-VCH GmbH. (B) A gut-on-a-chip mimicking the intestinal microenvironment to assess the metabolism of ifosfamide and verapamil. Reprinted with the permission from Ref. 158. Copyright © 2018 John Wiley and Sons. (C) A skin-on-a-chip model to evaluate the anti-inflammatory effect of dexamethasone. Reprinted with the permission from Ref. 162. Copyright © 2016 Springer Nature. (D) A blood-vessel-on-a-chip to study the anti-angiogenic effects of sorafenib and sunitinib. Reprinted with the permission from Ref. 166. Copyright © 2018 Elsevier.