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. 2023 Feb 15;13(6):2483–2509. doi: 10.1016/j.apsb.2023.02.006

Figure 7.

Figure 7

Tumor-on-a-chip devices for drug screening. (A) A breast-tumor-on-a-chip for screening the concentration-dependent toxicity of epirubicin and paclitaxel. Reprinted with the permission from Ref. 193. Copyright © 2020 Springer Nature. (B) A heart-breast-cancer-on-a-chip to investigate chemotherapy-induced cardiotoxicity (CIC) after treatment with doxorubicin. Reprinted with the permission from Ref. 197. Copyright © 2021 John Wiley and Sons. (C) A heart-colon-tumor chip for simultaneous evaluation of the anticancer effect and dose-dependent cardiotoxicity of doxorubicin and oxaliplatin. Reprinted with the permission from Ref. 198. Copyright © 2020 Mary Ann Liebert, Inc. (D) A biomimetic array chip combining liver and tumor microtissues to evaluate the hepatic metabolism-related anticancer efficacy of the prodrugs capecitabine and irinotecan, as well as their hepatoxicity. Reprinted with the permission from Ref. 200. Copyright © 2020 The Royal Society of Chemistry. (E) A 3D vascularized organotypic chip to investigate the anti-metastatic role of adenosine in breast cancer cell extravasation. Reprinted with the permission from Ref. 203. Copyright © 2000 National Academy of Science.