Table 5.

Pharmacokinetic parameters of R₁₀L₄^a.

Parameter	Unit	i.v.b	p.o.c
t1/2	h	1.61 ± 0.04	1.78 ± 0.25
Tmax	h	0.083 ± 0.00	0.83 ± 0.15
Cmax	ng/mL	657 ± 99.2	79.9 ± 14.8
AUC0–t	h·ng/mL	472 ± 63.4	199 ± 38.7
AUC0–∞	h·ng/mL	481 ± 63.3	203 ± 38.4
MRT0–∞	h	1.45 ± 0.09	2.27 ± 0.05
CL	mL/h/kg	4209 ± 552	–
F	%	–	8.5

^aPK parameters (mean ± SD, n = 3).

^bDosed intravenously at 2 mg/kg.

^cDosed orally at 10 mg/kg.