Figure 1.
Decreased SIRT6 expression and increased lactate accumulation were observed in the plasma of anthracyclines-treated cancer patients. (A) Ten breast cancer patients received postoperative adjuvant therapy with anthracyclines-based chemotherapy regimens, and plasma was collected before and after chemotherapy from same patients. SIRT6 expression in the plasma of cancer patients was measured by ELISA (n = 10 patients). (B) Lactate concentration in the plasma of cancer patients was measured (n = 10 patients). The data are expressed as the mean ± standard deviation. Two-tailed paired t tests were performed to determine significant differences. ∗∗∗P < 0.001.