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. 2023 May 23;3(6):100488. doi: 10.1016/j.crmeth.2023.100488

Figure 4.

Figure 4

Comparison of in-vitro-generated hPGCLCs with in vivo counterparts

(A) UMAP showing integrated single-cell transcriptomics data from Carnegie stage 7 human embryo and BMEx overlay method, highlighting BMEx overlay method (left) and human embryo cells (right).

(B) Expression of signature genes of cell types of interest on the UMAP plot from (A).

(C) UMAP showing integrated single-cell transcriptomics data from first and second trimester human fetal gonads and BMEx overlay method, highlighting BMEx overlay method (left) and human fetal gonads (right).

(D) Expression of signature genes of cell types of interest on the UMAP plot from (C).

(E) Heatmap with hierarchical clustering showing expression level of selected genes in the BMEx overlay and germ cell clusters from all analyzed RNA-seq datasets.