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. 2023 Jul 6;13(7):e1325. doi: 10.1002/ctm2.1325

FIGURE 3.

FIGURE 3

Hepatocyte‐specific overexpression of mitochondrial GCN5L1 aggravates NASH (A‐C) Hepatic mRNA (A), protein levels (B) and immunohistochemical (IHC) staining of GCN5L1 (C) in AAV‐control or AAV‐MtG mice fed with HFHC, or MCD diet. (D) Hematoxylin and eosin (H&E), Oil Red O, Masson, Sirius Red, and α‐SMA staining were shown in AAV‐control or AAV‐MtG mice fed with HFHC, or MCD diet. (E) Representative immunofluorescence (IF) staining showed Ly6G and F4/80. (F) Graphs showed the serum alanine transaminase (ALT) and aspartate aminotransferase (AST) in mice (n = 6/group). Scale bars indicate 50 μm for IHC and 20 μm for IF. Error bars represent mean ± SD. *p < 0.05.