TABLE 1.

Dose response.

	Veh	1.0 mg	3.0 mg	10.0 mg
Brain area	Med	Med	Med	Med	P val
Positive BOLD volume of activation
Primary somatosensory ctx trunk	0	0	17	0	0.008
Precuniform nucleus	0	0	1	0	0.013
1st cerebellar lobule	0	5	0	8	0.014
Motor trigeminal nucleus	2	0	4	2	0.016
Primary somatosensory ctx jaw	22	33	160	2	0.017
Supraoptic nucleus	1	0	0	1	0.019
Ventral posteriolateral thalamus	3	0	27	5	0.021
Primary motor ctx	34	32	275	15	0.022
Raphe linear	0	0	5	0	0.026
Primary somatosensory ctx shoulder	0	3	14	0	0.026
Root of trigeminal nerve	33	13	35	57	0.027
Premammillary nucleus	0	0	4	3	0.028
Median raphe nucleus	0	0	11	0	0.030
Infralimbic ctx	17	6	34	24	0.030
Endopiriform nucleus	2	3	26	0	0.031
Accumbens core	1	0	25	0	0.032
Paraflocculus cerebellum	84	28	54	121	0.033
Pineal gland	0	3	0	0	0.035
White matter	110	98	261	163	0.035
Insular ctx	42	42	203	26	0.035
Ventrolateral thalamus	0	1	15	0	0.037
Parvicellular reticular nucleus	36	17	29	68	0.039
Primary somatosensory ctx hindlimb	1	8	67	0	0.040
Claustrum	0	0	7	0	0.043
Parafascicular thalamus	4	0	42	5	0.045
Secondary motor ctx	15	27	118	10	0.047
Anterior thalamus	3	0	36	3	0.047
Reticular nucleus midbrain	28	30	82	40	0.051
Pontine reticular nucleus oral	3	1	44	4	0.052
CA3 dorsal	13	16	58	31	0.052
Pontine reticular nucleus caudal	7	1	20	3	0.054
Parietal ctx	3	0	33	3	0.057
Prelimbic ctx	14	2	59	11	0.058
Ventral anterior thalamic nucleus	0	0	10	0	0.059