Figure 4. Differentially expressed genes in trabecular meshwork cell populations of NC-Foxc2^-/- mice compared with Foxc2^fl/fl Controls and GO over-representation analysis.

(A, B, C, D) Volcano plots showing DEGs between NC-Foxc2^-/- and Foxc2^fl/fl Control mice in the trabecular meshwork 1 (A), trabecular meshwork 2 (B), trabecular meshwork 3 (C), and uveal meshwork clusters (D), left panels. Blue points denote DEGs with adjusted P-value < 0.05. Bar plots of subsets of GO gene sets that were overrepresented among the genes down-regulated (blue bars) or up-regulated (red bars) in NC-Foxc2^-/- mice compared with Foxc2^fl/fl Control mice, right panels. Values on the x-axis are represented as the –log₁₀(P-value) of each associated GO gene set.