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. 2023 Jul 6;6(9):e202201721. doi: 10.26508/lsa.202201721

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© 2023 Ujiie et al.

This article is available under a Creative Commons License (Attribution 4.0 International, as described at https://creativecommons.org/licenses/by/4.0/).

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Figure 5. — (A, B) sc-RNA seq analysis identifies differentially expressed genes related to MMPs between Control and NC-Foxc2^-/- mice in cells comprising the trabecular meshwork (A) and trabecular meshwork 3 (B) clusters. Violin plots showing differential expression of Adam19, Adamts5, Mmp2, and Mmp3 in the TM cluster (A) and TM-3 cluster (B) between Control and NC-Foxc2^-/- mice. Long, dashed lines denote median values. Statistical analysis: Mann–Whitney Test. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001. (C, D) Representative cross-section images of the iridocorneal angle and anterior chamber of a Foxc2^fl/fl control (C) and NC-Foxc2^-/- individual (D) immunostained with PDGFRβ, MMP2, VEGFR-3, and DAPI. Boxed regions in top panels denote magnified regions in lower panels. Scale bars are 500 μm and 50 μm, respectively. C, cornea; AC, anterior chamber; SC, Schlemm’s canal. (E) Quantification of sTIE2 in conditioned media from cultured HDLECs treated with DMSO vehicle or GM-6001 at 100 nM by ELISA (E). Data are mean ± SD from three biological replicates. Statistical analysis: Mann–Whitney U test. *P < 0.05.

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