Table 2.
SBDL model comparing estimated aging pace between healthy controls and WBRT patients. ψ > 1 indicated WBRT patients “aged” ψ-times faster than healthy controls. Intercept c serves as surrogate for pre-treatment difference in between WBRT patients and healthy controls. *Bonferroni cutoff p < 0.005 for uncorrected p-values.
| Structure | ψ (95% CI) | c (95% CI) | Uncorrected p-value* |
|---|---|---|---|
| Whole Brain | 9.32 (8.09, 10.56) | −0.079 (−0.209, 0.051) | <0.001 |
| Cortex | 8.05 (6.90, 9.21) | 0.077 (−0.046, 0.200) | <0.001 |
| Subcortical | 12.57 (10.77, 14.36) | −0.016 (−0.208, 0.176) | <0.001 |
| Nucleus Accumbens | 8.69 (7.20, 10.18) | −0.072 (−0.238, 0.095) | <0.001 |
| Amygdala | 6.43 (4.94, 7.92) | −0.037 (−0.192, 0.119) | <0.001 |
| Caudate | 7.84 (6.55, 9.14) | −0.075 (−0.214, 0.064) | <0.001 |
| Hippocampus | 10.15 (8.55, 11.75) | 0.021 (−0.154, 0.196) | <0.001 |
| Pallidum | 8.64 (7.11, 10.17) | 0.015 (−0.153, 0.182) | <0.001 |
| Putamen | 9.65 (8.01, 11.28) | 0.037 (−0.137, 0.211) | <0.001 |
| Thalamus | 7.59 (5.87, 9.30) | 0.237 (0.058, 0.417) | <0.001 |