Figure 2.

Kaplan–Meier curves showing progression-free survival (PFS, left) and overall survival (OS, right). Above diagrams show survival by histological tumor grade for the whole cohort of adult patients with diagnosis of ependymoma prior to DNA methylation profiling (A and B) and for the group of ependymal tumors confirmed by DNA methylation profiling (C and D). Notably, histological tumor grade was no longer a predictor of survival after exclusion of tumors that were non-ependymal and non-classifiable after DNA-methylation profiling. Panels (E and F) show that PFS and OS did not differ significantly between the three major molecular classes of adult intracranial ependymoma. Panels (G and H) show that confirmed ependymal tumors generally had a better PFS and OS in comparison to the groups of other tumor types and non-classifiable tumors as indicated by the classifier demonstrating the clinical importance of DNA methylation profiling.

Abbreviations: EPN-PFB = posterior fossa ependymoma group B, EPN-ZFTA = supratentorial ZFTA fusion-positive ependymoma, PF-SE/E = posterior fossa subependymoma molecular class with ependymoma histology.