Figure 4.

Intratumoral XUC treatment and combined therapy with GC induces necrosis, decreases the proliferation, but increases apoptosis of tumor cells. A. Representative H&E staining, Ki67 IHC and TUNEL assay of MBT-2 tumors with different treatments. Scale bar, 4 mm. B. Quantitation of the necrosis areas in MBT-2 tumors with different treatments. C. Quantitation of Ki67-positive cells on tumor sections of MBT-2 tumors with different treatments. D. Quantitation of apoptotic cells on tumor sections of MBT-2 tumors with different treatments. Scale bar, 100 μm. Data are presented as mean ± SD. *P<0.05; **P<0.01; ***P<0.001.