Table 2.
Univariate and multivariate Cox analysis of characteristics extracted from the SEER database
| Univariate Cox analysis | Multivariate Cox analysis | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
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| OS | BCSS | OS | BCSS | |||||||||
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| HR | 95% CI | P value | HR | 95% CI | P value | HR | 95% CI | P value | HR | 95% CI | P value | |
| Age at diagnosis | ||||||||||||
| <40 | Reference | Reference | Reference | Reference | ||||||||
| 40-49 | 0.809 | 0.581-1.127 | 0.210 | 0.792 | 0.557-1.126 | 0.194 | 0.969 | 0.675-1.391 | 0.865 | 0.911 | 0.622-1.336 | 0.633 |
| 50-59 | 0.912 | 0.666-1.249 | 0.567 | 0.901 | 0.646-1.258 | 0.540 | 1.069 | 0.757-1.509 | 0.707 | 1.080 | 0.751-1.553 | 0.677 |
| 60-69 | 0.994 | 0.721-1.370 | 0.970 | 0.795 | 0.558-1.131 | 0.202 | 1.114 | 0.777-1.596 | 0.558 | 0.925 | 0.623-1.372 | 0.698 |
| 70-79 | 1.842 | 1.327-2.556 | *** | 1.333 | 0.921-1.930 | 0.128 | 2.082 | 1.431-3.027 | *** | 1.620 | 1.063-2.469 | * |
| 80+ | 4.945 | 3.611-6.774 | *** | 2.380 | 1.624-3.486 | *** | 3.693 | 2.498-5.461 | *** | 2.123 | 1.320-3.413 | *** |
| HER2 | ||||||||||||
| Negative | Reference | Reference | Reference | Reference | ||||||||
| Positive | 0.695 | 0.578-0.836 | *** | 0.609 | 0.486-0.763 | *** | 0.594 | 0.479-0.736 | *** | 0.474 | 0.364-0.617 | *** |
| Race | ||||||||||||
| White | Reference | Reference | Reference | Reference | ||||||||
| Black | 1.039 | 0.836-1.292 | 0.729 | 0.981 | 0.755-1.274 | 0.884 | 1.081 | 0.844-1.383 | 0.539 | 0.951 | 0.703-1.288 | 0.746 |
| Other | 0.601 | 0.441-0.819 | ** | 0.641 | 0.451-0.912 | * | 0.563 | 0.391-0.811 | ** | 0.622 | 0.412-0.941 | * |
| Histological type | ||||||||||||
| IDC | Reference | Reference | Reference | Reference | ||||||||
| Non-IDC | 1.269 | 1.019-1.581 | * | 1.185 | 0.909-1.545 | 0.209 | 0.992 | 0.766-1.285 | 0.952 | 1.015 | 0.746-1.383 | 0.923 |
| Marital status | ||||||||||||
| Married | Reference | Reference | Reference | Reference | ||||||||
| Unmarried | 1.642 | 1.394-1.935 | *** | 1.348 | 1.113-1.634 | ** | 1.069 | 0.886-1.291 | 0.487 | 1.006 | 0.805-1.257 | 0.960 |
| T Stage | ||||||||||||
| T1 | Reference | Reference | Reference | Reference | ||||||||
| T2 | 1.749 | 1.435-2.133 | *** | 2.164 | 1.684-2.780 | *** | 1.643 | 1.310-2.060 | *** | 1.751 | 1.324-2.315 | *** |
| T3 | 2.891 | 2.189-3.819 | *** | 4.202 | 3.040-5.808 | *** | 2.860 | 2.047-3.996 | *** | 3.193 | 2.178-4.681 | *** |
| T4 | 6.357 | 4.910-8.230 | *** | 9.424 | 6.964-12.754 | *** | 4.740 | 3.380-6.645 | *** | 5.189 | 3.512-7.666 | *** |
| N Stage | ||||||||||||
| N0 | Reference | Reference | Reference | Reference | ||||||||
| N1 | 1.688 | 1.405-2.027 | *** | 2.275 | 1.828-2.831 | *** | 1.562 | 1.259-1.938 | *** | 1.883 | 1.459-2.430 | *** |
| N2 | 2.728 | 2.025-3.676 | *** | 3.895 | 2.787-5.444 | *** | 2.464 | 1.743-3.484 | *** | 3.040 | 2.067-4.470 | *** |
| N3 | 5.483 | 4.170-7.210 | *** | 8.692 | 6.469-11.680 | *** | 4.239 | 3.059-5.875 | *** | 5.739 | 4.020-8.193 | *** |
| Grade | ||||||||||||
| I | Reference | Reference | Reference | Reference | ||||||||
| II | 3.634 | 1.152-11.460 | * | 6.095 | 0.844-44.030 | 0.073 | 2.193 | 0.688-6.990 | 0.184 | 3.565 | 0.489-26.007 | 0.210 |
| III/IV | 4.274 | 1.373-13.300 | * | 9.676 | 1.359-68.880 | * | 2.665 | 0.846-8.401 | 0.094 | 5.023 | 0.698-36.154 | 0.109 |
| Median household income (inflation ajusted) | ||||||||||||
| <50,000 $ | Reference | Reference | Reference | Reference | ||||||||
| 50,000-59,999 $ | 0.880 | 0.677-1.144 | 0.339 | 0.829 | 0.609-1.130 | 0.236 | 0.890 | 0.665-1.191 | 0.433 | 0.775 | 0.547-1.097 | 0.150 |
| 60,000-69,999 $ | 0.759 | 0.604-0.954 | * | 0.758 | 0.581-0.989 | * | 0.738 | 0.570-0.955 | * | 0.711 | 0.526-0.963 | * |
| 70,000 $+ | 0.667 | 0.529-0.842 | *** | 0.635 | 0.483-0.834 | ** | 0.784 | 0.603-1.1020 | 0.069 | 0.761 | 0.559-1.034 | 0.081 |
| Surgery | ||||||||||||
| No | Reference | Reference | Reference | Reference | ||||||||
| Yes | 0.243 | 0.198-0.298 | *** | 0.240 | 0.189-0.305 | *** | 0.557 | 0.419-0.740 | *** | 0.576 | 0.412-0.805 | ** |
| Radiotherapy | ||||||||||||
| None/unknown | Reference | Reference | Reference | Reference | ||||||||
| Yes | 0.542 | 0.461-0.639 | *** | 0.682 | 0.565-0.823 | *** | 0.705 | 0.580-0.856 | *** | 0.821 | 0.655-1.030 | 0.089 |
| Chemotherapy | ||||||||||||
| No | Reference | Reference | Reference | Reference | ||||||||
| Yes | 0.464 | 0.396-0.545 | *** | 0.735 | 0.601-0.899 | ** | 0.546 | 0.433-0.689 | *** | 0.635 | 0.478-0.844 | ** |
| Neoadjuvant therapy | ||||||||||||
| No | Reference | Reference | Reference | Reference | ||||||||
| Yes | 0.953 | 0.764-1.189 | 0.668 | 1.261 | 0.987-1.612 | 0.064 | / | / | / | / | / | / |
SEER: the Surveillance, Epidemiology, and End Results. *P<0.05, **P<0.01, ***P<0.001.