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. 2023 May 31;73:101745. doi: 10.1016/j.molmet.2023.101745

Figure 2.

Figure 2

State dependent changes of NPY/AgRP and POMC neurons during and after exercise – involvement in neuroplasticity. The effects of exercise under different nutrient states on arcuate NPY/AgRP and POMC neuron activity is summarized from top to bottom (top: sedentary state, middle: during exercise, bottom: post exercise). The yellow cell represents an NPY/AgRP neuron, and the blue cell represents a POMC neuron. Inhibitory and excitatory synaptic inputs are represented by gray and red elliptical shapes on the surface of each neuron, respectively. The green arrow represents an increase in calcium activity and the red arrow represents a decrease in calcium activity. NPY/AgRP calcium activity during exercise is dependent on the nutrient state of the mouse; italicized as either ad libitum fed or held at 85–90% body weight. The straight pink arrows are pointing to changes in synaptic activity (either increased or decreased). The straight black arrows (in post exercise) are showing the time frame for these synaptic changes to happen. The black curved arrows from the post exercise to sedentary state indicate the duration that these synaptic changes persist following a bout of exercise before returning to the sedentary state (1 h–72 h later).