Figure 1.

The effect of PEVs in diverse pathophysiological processes. Activation of platelet by various stimuli including cancer, inflammation, pathogens, and injury leads to the release of EVs: exosomes, microvesicles, and apoptotic body The EVs can bundle active cargo such as proteins, nucleic acids, and lipids and convey it to a recipient cell, whether close or far away; thus, they can modify the destination cell’s pathophysiological functions including inflammation, cell communication, angiogenesis, coagulation, and metastasis in the process. “Created with BioRender.com”.