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. 2023 May 27;15(6):1262. doi: 10.3390/v15061262

Figure 1.

Figure 1

Interaction between the SARS-CoV-2 coronavirus spike protein and the host cell receptor ACE2 [72]. RBD—receptor; ACE2—angiotensin-converting enzyme 2; S1-, S2-, S2′- subunits of Spike (S) structural protein; TMPRSS2—Trans-membrane serine protease 2; Schematic of SARS-CoV-2 entry into the host cell. (A) presentation of protein S; (B) binding of protein S into S1 and S2 sites occurs. The activated S2 domain assists in the fusion of the SARS-CoV-2 molecule with the cell membrane. (Figure was created using templates available at BioRender.com, accessed 21 May 2023).