Table 1. Optimized Reaction Conditions: Standard Deviation Studies.

Entry	Deviation from Standard Reaction Conditiona	Conversion (%)	ee (%)
1	None	95 (81b)	96
2	0.5 M instead of 1 M	60	96
3	L2 instead of L1	43	83
4	L3 instead of L1	50	92
5	L4 instead of L1	70	92
6	Cs2CO3 instead of aq. CsOH	75	94
7	No aq. CsOH	40	96
8	Cs2CO3 instead of aq. CsOH; no H2O	<5	–
9	No [Rh(cod)(OH)]2	<5	–
10	No Ligand	<5	–

^aReaction conditions: 1 (0.5 mmol, 1 equiv), 2a (1.5 mmol, 3 equiv), [Rh(cod)(OH)]₂ (0.015 mmol, 3 mol%), ligand (0.035 mmol, 7 mol%), aq. CsOH (1 mmol, 2 equiv), THP:Tol (1:1, 0.5 mL), H₂O (0.25 mL), 70 °C, 20 h.

^bIsolated yield (%).