Table 2.
Gentamicin MIC against P. aeruginosa strains PA7 and PA14 in the absence and presence of berberine or select analogs.
| Strain | Gentamicin MIC, μg/mL (fold change)a,b,c | ||||
|---|---|---|---|---|---|
| - | Berberine | Ber-C3 [5] | Ber-C12 [9] | Ber-pAr [10] | |
| PAO1 | 1 | 0.5 (2) | 0.25 (4) | 0.125 (8) | 0.25 (4) |
| PA7 | 256 | 128/64 (2/4) | 32 (6) | 32 (6) | 64 (4) |
| PA14 | 2 | 2/1 (-/2) | 1 (2) | 1 (2) | 2/1 (-/2) |
a
Berberine or analog included at 64 μg/mL.
b
MIC data for PAO1 are the same as in Table S4 and are shown for ease of comparison.
c
fold change is relative to respective to wild-type PAO1, PA7, or PA14, (−) represents no fold change