Figure 9. Experimentally measured and modeled intracellular calcium ${\left[\text{Ca}\right]}_{\text{i}}$ in male and female vessels and response to clinically used L-type $\text{C}{\text{a}}^{\text{2+}}$ channel blocker.

A) Intracellular calcium ${\left[\text{Ca}\right]}_{\text{i}}$ in female (blue symbols) and male (black symbols) arteries at intravascular pressures ranging from 20 to 120 mmHg. Simulations showing ${\left[\text{Ca}\right]}_{\text{i}}$ in the idealized female and male vessels are shown with blue and black solid lines, respectively. Simulated ${\left[\text{Ca}\right]}_{\text{i}}$ after the application of clinically used L-type $\text{C}{\text{a}}^{\text{2+}}$ channel blocker nifedipine is shown with dashed lines for male (black) and female (blue). B) Comparison of the percentage change of ${\left[\text{Ca}\right]}_{\text{i}}$ in male (black) and female (blue) after the application L-type $\text{C}{\text{a}}^{\text{2+}}$ channel blocker nifedipine at 80 mmHg and 120 mmHg. *P < 0.05, **P < 0.01.